Training and rehabilitation

Physical exercise was for long considered deleterious for patients with neuromuscular diseases, because of strain on the musculature, which was thought to accelerate the disease process. Our research unit has produced a large body of evidence that exercise is not only well tolerated, but also highly beneficial in patients with muscle diseases. There are still many unsolved issues related to physical rehabilitation of patients with neuromuscular diseases, which we are currently investigating. These include studies on of training patients with very severe muscle weakness, using anti-gravity treadmill training, using other modes of training, such as high-intensity training, and studying the effect of supplements that may enhance exercise performance.


  • Andersen G, Løkken N, Vissing J. Aerobic training in myotonia congenita: effect on myotonia and fitness. Muscle Nerve 2017; [Epub ahead of print].
  • Jensen BR, Berthelsen MP, Husu E, Christensen SB, Prahm KP, Vissing J. Body weight-supported training in Becker and limb girdle muscular dystrophy. Muscle Nerve 2016; 54(2): 239-243.
  • Hedermann G, Vissing CR, Heje K, Preisler N, Witting N, Vissing J. Aerobic training in patients with congenital myopathy. PLoS One 2016 Jan 11;11(1):e0146036. doi: 10.1371/journal.pone.0146036. 184.
  • Andersen G, Prahm KP, Dahlqvist JR, Citirak G, Vissing J. Aerobic training and post-exercise protein in facioscapulohumeral muscular dystrophy: RCT study. Neurology 2015 4; 85(5): 396-403.
  • Andersen G, Ørngreen MC, Preisler N, Jeppesen TD, Krag TO, Hauerslev S, van Hall G, Vissing J. Protein-carbohydrate supplements improve muscle protein balance in muscular dystrophy patients after endurance exercise: a placebo controlled crossover study. Am J Physiol Regul Integr Comp Physiol 2015; 308(2): R123-R130
  • Madsen KL, Hansen RS, Preisler N, Thøgersen F, Berthelsen MP, Vissing J. Training improves oxidative capacity, but not function, in spinal muscular atrophy type III. Muscle Nerve 2015; 52(2): 240-244.
  • Berthelsen MP, Husu E, Christensen SB, Prahm KP, Vissing J, Jensen BR. Anti-gravity training improves walking capacity and postural balance in patients with muscular dystrophy. Neuromuscul Disord 2014 Mar 12. pii: S0960-8966(14)00076-5. doi: 10.1016/j.nmd.2014.03.001.
  • Vissing CR, Preisler N, Husu E,Prahm K, Vissing J. Aerobic training in patients with myopathy and hyperCKemia caused by anoctamin 5 deficiency. Muscle Nerve 2013 Nov 6. doi: 10.1002/mus.24112.
  • Riisager M, Mathiesen P, Vissing J, Preisler N, Ørngreen MC. Aerobic training in persons who have recovered from juvenile dermatomyositis. Neuromuscl Disord 2013; 23(12): 962-968.
  • Andersen SP, Sveen ML, Hansen RS, Madsen KL, Hansen JB, Madsen M, Vissing J. Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy. Muscle Nerve 2013; 48(6): 897-901.
  • Sveen ML, Andersen SP, Ingelsrud LH, Blichter S, Olsen NE, Jønck S, Krag TO, Vissing J. Resistance training in patients with Limb Girdle and Becker muscular dystrophies. Muscle Nerve 2013; 47: 163-169.
  • Mathiesen P, Ørngreen MC, Vissing J, Andersen LB, Herlin T, Nielsen S. Aerobic fitness after juvenile dermatomyositis – a long-term follow-up study. Rheumatology 2013; 52: 287-295.
  • Preisler N, Andersen G, Thøgersen F, Crone C, Jeppesen TD, Wibrand F, Vissing J. Effect of aerobic training in patients with spinal and bulbar muscular atrophy (Kennedy disease). Neurology 2009; 72(4): 317-323
  • Jeppesen TD,Duno M,Schwartz M,Krag T,Rafiq J, Wibrand F,Vissing J. Short- and long-term effects of endurance training in patients with mitochondrial myopathy. Eur J Neurol 2009; 16: 1336-1339.
  • Sveen ML, Jeppesen TD, Hauerslev S, Køber L, Krag TO, Vissing J. Endurance training improves fitness and strength in patients with Becker muscular dystrophy. Brain 2008; 131: 2824-2831.
  • Sveen ML, Jeppesen TD, Hauerslev S, Krag TO, Vissing J. Endurance training: An effective and safe treatment for patients with LGMD2I. Neurology 2007; 68: 59-61.
  • Haller RG, Wyrick P, Taivassalo T, Vissing J. Aerobic conditioning: An effective therapy in McArdle disease. Ann Neurol 2006; 59: 922-928.
  • Olsen DB, Ørngreen MC, Vissing J. Aerobic training improves exercise performance in facioscapulohumeral muscular dystrophy. Neurology 2005; 64: 1064-1066.
  • Ørngreen, MC, Olsen DB, Vissing J. Aerobic training in patients with myotonic dystrophy type I. Ann Neurol 2005; 57: 754-757.