With collaborators in Spain and the creators of the model, we are investigating the physiology of the muscle glycogenosis V (McArdles disease) mouse model and how the metabolic signaling is altered in these mice and the effect on glycogen build-up.
As the main model for developing therapies to muscular dystrophies, we are using the Duchenne muscular dystrophy mouse model, the mdx mouse. We are developing therapies more broadly applicable to muscular dystrophies by focusing on how muscle regeneration can be boosted, rather than attempting to cure one particular muscular dystrophy. We have found that growth factor mediated activation of muscle stem cells leads to increased regeneration in the mdx mouse, a decrease in creatine kinase and an increase in muscle mass. We are currently investigating how the regeneration boosting therapy can be improved by circumventing the myostatin-mediated negative feedback on regeneration signaling.
All animals are housed at the University of Copenhagen Faculty of Health and Medical Sciences animal facility.